NF1 and SPRED1/2 cooperate through RAS-MAPK-independent functions
Jillian M. Silva, Lizzeth Canche, Alice Cheng, Lucy C. Young et autres
Neurofibromin, the protein product of the neurofibromatosis type 1 ( NF1 ) gene, requires the direct binding interaction with SPRED to negatively regulate the RAS-MAPK pathway. Although the region of neurofibromin that stimulates the intrinsic GTPase activity of RAS represents only a …
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Proceedings of the National Academy of Sciences