Yen Ying Lim

Barriers and enablers to the implementation of dementia biomarkers into clinical practice: a scoping review protocol

Hannah Gulline, Sarah Carmody, Yen Ying Lim, Darshini Ayton et autres

The landscape of dementia care is undergoing a foundational paradigm shift driven by advancements in fluid (cerebrospinal fluid and blood-based) and neuroimaging (PET, SPECT, MRI) biomarkers. These diagnostic tools enable accurate, biologically specific identification of neuropathology early in the disease trajectory, a …

Exploring the relationship between methylation of the cortisol receptor genes and brain and cognitive outcomes in individuals with elevated amyloid-β

Ayeisha Milligan Armstrong, Lidija Milicic, Michael Vacher, Shane Fernandez et autres

Chronic psychological stress has been implicated as a risk factor for Alzheimer’s disease (AD), potentially through cortisol-mediated acceleration of disease progression. However, the molecular pathways underlying this relationship remain poorly understood. Epigenetic regulation of the glucocorticoid and mineralocorticoid receptor genes ( NR3C1 …

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Associations of self‐reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle‐aged adults

Gabriel T. Abdelmessih, Lisa Bransby, Hannah Cummins, Melinda L. Jackson et autres

INTRODUCTION: Obstructive sleep apnea (OSA) is a potential risk factor for cognitive impairment and dementia; however, its contribution in midlife and interactions with APOE ε4 remain unclear. METHODS: Participants were 2795 cognitively unimpaired, middle-aged adults enrolled in the Healthy Brain Project. OSA …

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Analysis of second-generation epigenetic clocks reveals further associations between disproportionate biological ageing and hippocampal volume

Lidija Milicic, Michael Vacher, Vincent Doré, Pierrick Bourgeat et autres

Age acceleration, or the difference between biological and chronological age, is a research area of growing interest, particularly in the field of age-related and neurodegenerative disorders, including Alzheimer's disease (AD). First-generation epigenetic clocks that predict chronological age utilising DNA methylation data were …

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A computational model to describe multi-regional brain architecture during neurodegeneration in Alzheimer’s disease

Xingfeng Li, Andrea G. Rockall, Paul Edison, Alzheimer’s Disease Neuroimaging Initiative (ADNI) et autres

We previously proposed an MRI-based machine learning model to describe the mesoscopic architecture of the human brain to aid in classifying subjects as having non-AD related pathology (nADrp) or AD related pathology (ADrp), including mild cognitive impairment (MCI) and Alzheimer's disease (AD). …

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Consumer Perspectives Regarding Cognitive Assessment and Internet-Based Methods for Diagnosing Alzheimer’s Disease: A Mixed-Methods Study (Preprint)

Michael Williamson, Laura Bird, Renerus J Stolwjk, Paul Maruff et autres

BACKGROUND The increasing prevalence of dementia, alongside limitations in clinical workforce capacity, highlights the need for more accessible and scalable approaches to cognitive assessment. Internet-based cognitive assessment, including digital cognitive tests (DCTs) and cognitive assessment via telehealth (CATH), provides a potential solution. …

Australian & New Zealand Journal of Psychiatry 1 –11 DOI: 10.1177/0004867414557161

The Royal Australian, Karra D Harrington, Yen Ying Lim, Emma Gould et autres

Australian & New Zealand Journal of Psychiatry Converging clinical evidence suggests that in otherwise healthy older adults an increase in depressive symptoms can be an early or preclinical indicator of dementia (Byers and Yaffe, 2011). The most common type of dementia, Alzheimer’s …