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2026
article
OpenAlex
Alba Carrillo-Moreno, María Gabriela Álvarez-Rodríguez, Sergio Martínez‐Rodríguez, Pablo Soriano‐Maldonado et autres
Xylan, the principal component of hemicellulose, requires the concerted action of endo- and exo-acting xylanolytic enzymes for its complete depolymerization into fermentable sugars. This study reports the biochemical and thermodynamic characterization of a glycoside hydrolase family 10 endo-β-1,4-xylanase from the thermophilic bacterium …
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Accès ouvert
2026
article
OpenAlex
María Gabriela Álvarez-Rodríguez, Emanuel Capone, Sonia Vega, Virginia Rejas et autres
The Polycomb repressive complexes can be considered a paradigm of chromatin-based gene regulation in animals. Two of the proteins involved in such complexes are the Ring finger protein 1 (RING1) and the intrinsically disordered protein RING1A and YY1 binding protein (RYBP), which …
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Accès ouvert
2026
article
OpenAlex
María Gabriela Álvarez-Rodríguez, Sonia Vega, Felipe Hornos, Adrián Velázquez‐Campoy et autres
Protein kinases have key roles in cells as they regulate diverse signal transduction pathways. Mitogen-activated protein kinase (MAPK) signaling route modulates several processes, such as cell proliferation, cell programming, metabolic changes and stress responses. Within the group of proteins participating in this …
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Accès ouvert
2026
article
OpenAlex
María Gabriela Álvarez-Rodríguez, Sonia Vega, Felipe Hornos, Augusto Fienco-Bacusoy et autres
H NMR experiments. All the peptides were capable of binding to PADI4 with low micromolar affinities, but their affinity decreased as the fraction of citrullination increased. Moreover, all peptides could bind to both importin species with affinities in the low micromolar range, …
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Accès ouvert
2026
article
OpenAlex
Laureano E. Carpio, María Gabriela Álvarez-Rodríguez, David Recio-Moreno, Felipe Hornos et autres
Cancer cells must maintain molecular mechanisms relying on an energy trade-off between resistance and key functions to survive. PADI4 (peptidyl arginine deiminase 4) is an enzyme implicated in the conversion of arginine to citrulline (citrullination), that has been related to the development …
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