Human islet amyloid polypeptide aggregation upregulates the mitochondrial cholesterol transport protein StAR and induces mitochondrial dysfunction in beta cells
Meghan F. Hogan, Rehana Akter, Alfred C. Aplin, Andrew T. Templin et autres
AIMS/HYPOTHESIS: Loss of islet beta cell function and mass are critical in the pathogenesis of type 2 diabetes, a disease in which ~90% of individuals exhibit islet amyloid deposition. Amyloid deposits comprise the normal beta cell secretory product, human islet amyloid polypeptide …
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Diabetologia