Andrés Opazo-Capurro

Genomic insights into the first blaKPC-2-carrying Klebsiella pneumoniae isolate reported in Chile: limited local dissemination of the globally distributed ST101 lineage

Maximiliano Matus-Köhler, Camilo Berríos-Pastén, Nicolás Guerra-Leal, Nahuel Pilquinao et autres

ABSTRACT Objective To genomically characterize Kpn-KPC-1, the first bla KPC-2 -carrying Klebsiella pneumoniae isolate reported in Chile, and contextualize it within the global ST101 lineage. Methods Kpn-KPC-1 was analyzed by whole-genome sequencing. Its resistome, virulome, plasmid content, and bla KPC-2 genetic context …

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Genomic characterization and global phylogenomic placement of a high-level azithromycin (HL-AziR) and fluoroquinolone-resistant Neisseria gonorrhoeae ST9363 strain from Chile

Alejandro Aguayo-Reyes, Mario Quezada-Aguiluz, Henriette Chabouty-García, Paulina González-Muñoz et autres

Background: Antibiotic-resistant Neisseria gonorrhoeae (Ng) is a WHO priority pathogen and represents a serious public health threat. This study reports the first Chilean Ng ST9363 isolate (GC11/23) exhibiting dual high-level resistance to azithromycin and fluoroquinolone, recovered from a urethral discharge sample in …

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Changing landscape of 16 S-RMTase-mediated aminoglycoside resistance in clinical Klebsiella pneumoniae isolates from Chile between 1997 and 2023

Maximiliano Matus-Köhler, Rocío Rivas-Carrasco, Luis Amsteins-Romero, Mario Quezada-Aguiluz et autres

The emergence of 16S rRNA methyltransferase (16S-RMTases) poses a major therapeutic challenge, as they confer high-level resistance to all clinically relevant aminoglycosides. In Chile, data on these enzymes remain scarce. This study investigated the epidemiological distribution and genetic relatedness of Klebsiella pneumoniae …

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Caracterización fenotípica y genotípica de cepas extraintestinales patogénicas de Escherichia coli aisladas en el Gran Concepción entre 2024-2025

Néstor Andrés Herrera Chávez, Javiera Torres, Javier Zenis, Nicolás Schnake et autres