Peng Qu

Biomaterial-based mitochondria-targeted nanomedicine for remodeling the breast cancer tumor microenvironment and overcoming therapy resistance

Yao Gu, Peng Qu, Xue Li, Jiao Shi et autres

cn (code pays fourni par la source)

Regulatory mechanisms of dynamic mitochondria–macrophage interactions in myocardial ischemia–reperfusion injury and materials-based targeted therapy

Zongze Bai, Peng Qu, MingZhi Zhou, Jiao Shi et autres

Myocardial ischemia–reperfusion injury (MIRI) is a major determinant of prognosis in ischemic heart disease. Its pathological basis extends beyond cardiomyocyte injury to include the release of mitochondrial stress signals and remodeling of the immune microenvironment. This review focuses on the “mitochondria–immune axis” …

cn (code pays fourni par la source)

Ion-Responsive Microneedles Delivering Subtype-Specific Mitochondrial Extracellular Vesicles from HEY1⁺ Cardiomyocytes for Cardiac Repair in Bama Minipigs with Myocardial Ischemia–Reperfusion Injury

Peng Qu, Jiao Shi, Xue Li, Yao Gu et autres

CM-derived exosomes to achieve stable, targeted delivery. We designed a responsive microneedle patch based on local copper/iron ion dynamics to enable the stage-specific release of these mitochondria within the ischemic or reperfusion microenvironments. In a Bama minipig MI/R model, this system significantly …

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Three-dimensional biofabrication strategies toward vascularized organoid and organoid-inspired models

Jiao Shi, Mingzhi Zhou, Zongze Bai, Yao Gu et autres

Organoids are three-dimensional multicellular models generated through the intrinsic self-organization of stem cells and have emerged as powerful platforms for disease modeling, drug screening, and precision medicine. However, most organoids cultured in vitro lack a functional vascular interface, which restricts oxygen and …

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Research progress on precision targeted therapy strategies for breast cancer based on tumor microenvironment

罗云波, Panlin Xie, Shaokang Yang, Peng Qu et autres

The tumor microenvironment (TME) plays a crucial role in the progression of BC, characterized by abnormal pH, aberrant enzyme expression, redox imbalance, etc. Nano-drug delivery systems (NDDSs) responsive to TME have emerged, including pH-responsive, enzyme-responsive, redox-responsive, and multi-responsive intelligent cascading systems. These …

cn (code pays fourni par la source)