Xuan Wang

A phase II peri-operative study of pembrolizumab plus lenvatinib for mucosal melanoma

Lili Mao, Yumei Lai, Hong Zheng, Ming Cui et autres

Abstract Mucosal melanoma is an aggressive malignancy with limited neoadjuvant options. We conducted a single arm, phase II study of neoadjuvant pembrolizumab plus lenvatinib followed by surgery and adjuvant pembrolizumab in resectable mucosal melanoma (NCT04622566) along with exploratory biomarker analysis. Primary objective …

cn, Éthiopie (code pays fourni par la source)

Identification and characterization of 15 265 super-Nyquist frequencies in 1309 δ Scuti stars from Kepler photometry

莫言起, Weikai Zong, Xuan Wang, Simon Murphy et autres

The frequency of the pressure (p) mode in δ Scuti stars can exceed the Nyquist limit of Kepler long-cadence photometry. These “superNyquist frequencies” (SNFs) are observed as “reflected” peaks at lower frequencies, i.e., they are Nyquist aliases that pose a threat to …

cn, fr, au, pt (code pays fourni par la source)

Sequence determinant and functional relevance of 8-oxoguanine RNA modification unveiled from foundation-model-based predictor

Order of Authors: Rong Xia, Jiahao Zhang, Xuan Wang, Jiongming Ma et autres

G prediction and (2) freely available source code and processed datasets.

cn, gb (code pays fourni par la source)

Virus-carried antibiotic resistance genes in diverse habitats: risk and divergence

Lijuan Li, Boya Gao, Aiyu Zhao, Xuan Wang et autres

抗生素抗性基因在环境中广泛传播，对公共健康和生态系统构成威胁。病毒作为抗性基因的储存与传播载体，其作用日益受到关注。但病毒携带抗性基因在不同生境中的空间格局、风险水平及驱动因素，仍缺乏系统认知。本研究汇总了780份来自污水处理厂、垃圾渗滤液、塑料际、土壤、湖泊沉积物、降雨及湿地的环境样品宏基因组数据，采用统一分析流程，系统分析了病毒抗性基因的组成特征、风险等级、宿主关联及主要来源。结果表明，病毒抗性基因的分布受生境影响明显。人工生境中，高风险抗性基因丰度显著高于自然环境，约为其15倍；自然生境则是低风险抗性基因占优。塑料际环境的抗性基因亚型多样性最高，可能成为抗性基因的潜在储存与交换热区。跨生境的核心抗性组为20个低风险抗性基因。病毒类群分析显示，Uroviricota病毒在人工生境中占主导，是抗性基因的主要携带者。湿地病毒抗性组溯源结果表明，土壤是其主要来源。本研究揭示，人类活动强度显著调控病毒携带抗性基因的分布，环境管理和公共卫生策略中，应优先关注人类高强度活动区域，以便识别关键耐药扩散节点并实施分区防控，降低抗性基因传播风险。

us, cn (code pays fourni par la source)

Author response for "Clinicopathological features and outcomes of SMARCA4-deficient carcinomas of the stomach and gastroesophageal junction: a case series and literature review"

Shao-Jie Sheng, Ting Lei, Xuan Wang, Yong-Qiang Shi et autres

Author response for "Clinicopathological features and outcomes of SMARCA4-deficient carcinomas of the stomach and gastroesophageal junction: a case series and literature review"

Shao-Jie Sheng, Ting Lei, Xuan Wang, Yong-Qiang Shi et autres