Accès ouvert
2026
article
OpenAlex
Mingguang Cui, Xiaoxuan Liu, Tien‐Hung Lan, Tianlu Wang et autres
Precise control of protein function in living cells is essential for engineering programmable biological systems and therapeutic applications. However, most current strategies act indirectly by altering protein stability, localization, or proximity rather than directly modulating binding activity. Here we present VIPbodies, nanobodies …
us
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Accès ouvert
2026
article
OpenAlex
Tatsuki Nonomura, Brendan McKee, Anna Price, Mingguang Cui et autres
High Resolution Image Download MS PowerPoint Slide Chemically induced proximity (CIP) and chemically disrupted proximity (CDP) technologies have transformed biological research by enabling precise temporal control of protein–protein interactions and cellular functions. However, despite the extensive development of CIP systems, CDP tools …
us, fr
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2026
article
OpenAlex
Tatsuki Nonomura, Tianlu Wang, Yubin Zhou
Background/Objectives: Protein-protein interactions (PPIs) underlie a wide range of physiological processes, and their precise control is central to synthetic biology and cellular engineering. Chemically induced proximity (CIP) systems use small molecules to regulate PPIs, enabling remote control of signaling and gene expression. …
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Accès ouvert
2026
article
OpenAlex
Sebin Abraham, Chaoyang Zhu, Lai Hoang Son Le, Yugendar R. Alugubelli et autres
High Resolution Image Download MS PowerPoint Slide Mutant RhoA G17V is a clinically significant yet historically undruggable oncogenic GTPase that drives angioimmunoblastic T-cell lymphoma through a neomorphic interaction with the guanine nucleotide exchange factor Vav1. Its rigid GTPase fold, absence of deep …
us, no
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Accès ouvert
2026
article
OpenAlex
Xiaoxuan Liu, Sher Ali, Tien-Hung Lan, Decheng Wang et autres
Store-operated Ca2+ release-activated Ca2+ (CRAC) channels, composed of STIM and ORAI, are essential for immune and developmental processes, and their dysregulation underlies channelopathies such as Stormorken syndrome. Here, we report the engineering of genetically encoded CRAC channel inhibitory binders (CRABs) derived from …
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