Farnesoid X Receptor Activation Upregulates Expression of the Transcription Elongation Factor, TCEA2, in Intestinal Epithelial Cells
Jessica Smyth, Jennifer Foulke-Abel, Ruxian Lin, Mark Donowitz et autres
BACKGROUND: Oxidative DNA damage occurs during mucosal inflammation, with such lesions stalling RNA polymerase II and impairing transcription fidelity, thereby driving genomic instability, a hallmark of cancer. TCEA2 (TFIIS) is a transcription elongation factor that rescues stalled polymerases by stimulating transcript cleavage, …
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Physiology