Liudmila Leppik

Traumatic Brain Injury in the Omics Era: Plasma and Extracellular Vesicle Proteomic Signatures in Polytrauma

Liudmila Leppik, Birte Weber, Cora Rebecca Schindler, Louise Funda et autres

Background/Objectives: Clinical outcomes after traumatic brain injury (TBI) remain difficult to predict, highlighting the need for more sensitive diagnostic and prognostic biomarkers, particularly in polytrauma. This study aimed to identify TBI-specific proteomic signatures in plasma and extracellular vesicles (EV)-enriched fractions of critically …

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Extension of the fluidics NTF-Biobank of polytraumatized patients with extracellular vesicles: improved vesicle preservation through local processing

Birte Weber, Liudmila Leppik, Jiaoyan Han, Nils Becker et autres

PURPOSE: Extracellular vesicles (EVs) show diagnostic relevance in trauma, prompting the development of the NTF‑EV‑Biobank as an extension of the established Network Trauma Research (NTF) plasma/serum biobank. After optimizing the EV isolation and characterization standard operating procedure (SOP) at a single center, …

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When trauma hits the heart: Divergent ventricular responses at histological and molecular levels in pigs

Birte Weber, Tamara Pavlovic, Ruth Brenner, Liudmila Leppik et autres

BACKGROUND: Cardiac damage after polytrauma (PT) is associated with increased mortality. The aim of the present study was to investigate histopathological and transcriptomic changes in the right (RV) and left ventricle (LV) following PT. METHODS: A porcine PT model was conducted in …

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Extracellular Vesicle and Plasma miRNAs as Candidate Biomarkers of Traumatic Brain Injury in the Context of Polytrauma

Cora Rebecca Schindler, Dirk Henrich, Lena Krämer, Inna Schaible et autres

Severe traumatic brain injury (TBI) is a leading cause of mortality and long-term disability in polytrauma (PT) patients, and its clinical outcome remains difficult to predict due to clinical heterogeneity and secondary injury mechanisms. Current diagnostic and prognostic approaches based on clinical …

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The roles of extracellular vesicles in sepsis and systemic inflammatory response syndrome

Birte Weber, Dirk Henrich, Frank Hildebrand, Ingo Marzi et autres