Reece Larson

Systemic hypoxia drives glycogen-fueled progression of lung adenocarcinoma

Harrison A. Clarke, Cameron J. Shedlock, Haley Peters, Tara R. Hawkinson et autres

Summary In advanced stages, lung adenocarcinoma obstructs airways and disrupts ventilation-perfusion relationships in the lung, causing systemic hypoxemia and enabling a feed-forward loop that accelerates malignancy. Systemic hypoxemia is also experienced due to common respiratory comorbidities such as chronic obstructive pulmonary disease …

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A multi-organ spatial metabolomic atlas of exercising mice reveals neuronal Complex I as a convergent and sufficient axis for tau pathology reduction in PS19

Terrymar Medina, Sadi Quiñones, Zizhen Liu, Lei Wu et autres

We constructed a spatially resolved metabolomic atlas of long-term exercise across six major organs in wild-type mice: brain, heart, lung, liver, kidney, and skeletal muscle, cataloguing 224 metabolic features and revealing coordinated inter-organ remodeling. Surprisingly, the brain showed particularly pronounced region-specific adaptation. …

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Metabolic Coherence of the Mouse Brain

Zizhen Liu, Xin Ma, Roberto A. Ribas, Terrymar Medina et autres

The brain's metabolic demands are well established, but how metabolism is coordinated across anatomically distinct regions remains poorly understood. Here, using matrix-assisted laser desorption/ionization (MALDI) imaging integrated with the Allen Brain Atlas and optimal transport-based computational analysis, we map the spatial metabolome …

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Abstract 4020 Glycogen Accumulation and N-Glycan Remodeling Shape Ewing Sarcoma Progression

Haley Peters, Yueying Liu, Xin Ma, Reece Larson et autres

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