Jing Qu

A framework of biomarkers for renal aging: a consensus statement by the Aging Biomarker Consortium

Xi Zhang, Anqun Chen, Linli Lv, Liang Ma et autres

Renal aging involves structural and functional kidney decline (reduced size/nephrons, glomerulosclerosis, tubular atrophy, functional loss) and is an independent risk factor for kidney and systemic degenerative diseases. On 16 May 2025, the Aging Biomarker Consortium convened an expert consensus meeting in Shanghai, …

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The ancient viral whispers of ageing: awakening the dark genome

Haitao Zhang, Guang-Hui Liu, Jing Qu

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Intervening in aging and related diseases with gene therapy techniques

Mengmeng Jiang, Jing Qu, Moshi Song, Guang‐Hui Liu

Aging is the primary risk factor for most chronic diseases, and the global rise in aging populations presents an escalating challenge due to functional decline and multimorbidity. Gene therapy provides a versatile framework for modulating aging-regulatory pathways, such as epigenetic regulation, telomere …

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The entropic view of aging: from thermodynamics to biology

Zeming Wu, Shuai Ma, Si Wang, Moshi Song et autres

A growing body of evidence suggests that aging is not simply the accumulation of damage, but a systemic progression of increasing entropy across biological scales. Synthesizing concepts from thermodynamics and information theory, we outline a tentative three-stage entropy model of the lifespan: …

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Multimodal clocks of human aging

Jiaming Li, Beier Jiang, Wei Zhang, Wei Zhang et autres

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PARKIN overexpression confers cardioprotection via suppressing the mtDNA-cGAS-STING axis in myocardial ischemia/reperfusion injury

Yujing Li, Yi Wang, Hao Zhang, Ping Xu et autres

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Vitamin C alleviates aging defects in a stem cell model for Werner syndrome

Ying Li, Weizhou Zhang, Liang Chang, Yan Han et autres

Werner syndrome (WS) is a premature aging disorder that mainly affects tissues derived from mesoderm. We have recently developed a novel human WS model using WRN-deficient human mesenchymal stem cells (MSCs). This model recapitulates many phenotypic features of WS. Based on a …

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