R J Schwab

Changes to Pharyngeal Soft Tissue and Fat Volumes Following Tirzepatide Treatment in SURMOUNT-OSA

R J Schwab, A Malhotra, R Grunstein, A Wiemken et autres

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0589 Concomitant Aroxybutynin and Atomoxetine (AD109) with GLP-1 Agonists: An Analysis of the SynAIRgy and LunAIRo Trials in Obstructive Sleep Apnea

Patrick Strollo, Huy Pho, Neomi Shah, R J Schwab et autres

Abstract Introduction AD109, an investigational oral anti-apneic neuromuscular modulator, combines in one tablet the novel antimuscarinic, aroxybutynin (2.5 mg), with the selective norepinephrine reuptake inhibitor, atomoxetine (75 mg). AD109 significantly improved the apnea-hypopnea index and oxygenation vs placebo (PBO) in two phase …

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0500 Understanding Contributions of Upper Airway Anatomy to OSA Risk in Lean and Obese Patients: Results from the EXPO Study

Bruno Saconi, Brendan Keenan, Andrew Wiemken, Nathan Nowalk et autres

Abstract Introduction Obstructive sleep apnea (OSA) is strongly influenced by upper-airway anatomy, with increased soft tissue size thought to be particularly important in obese patients and craniofacial restriction thought to be more important in lean patients. However, obesity alone do not fully …

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0527 Obstructive Sleep Apnea Patient Journey from First Symptom to Confirmed Diagnosis: A Real-world Analysis of Patients in the United States

Chris Schmickl, Kristina Yu, Lauren Lee, James D. Jackson et autres

Abstract Introduction Obstructive sleep apnea (OSA) results in repetitive collapse of the upper airway during sleep, leading to arousals and intermittent hypoxia. Despite its high prevalence and associated cardiovascular and neurocognitive risks, most cases remain undiagnosed and untreated. Variations in healthcare providers …

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0499 The Relationship Between Tongue Force, OSA and Upper Airway Anatomy, Assessed by MRI

Nathan Nowalk, Brendan Keenan, Bruno Saconi, Andrew Wiemken et autres

Abstract Introduction The pathogenesis of obstructive sleep apnea (OSA) is multifactorial and likely involves reduced activation of upper airway (UA) dilator muscles during sleep. The genioglossus, the primary tongue protrusor, contracts with each inspiration to prevent posterior tongue collapse and maintain airway …

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