Trisha J. Grevengoed

Early pregnancy GDF15 trajectories and their association with normal gestation, pregnancy loss, and hyperemesis gravidarum

Jens Skjoldan Svenningsen, Anne Ostenfeld, Jesper Friis Petersen, Mikkel Skjoldan Svenningsen et autres

BACKGROUND: Growth differentiation factor 15 (GDF15) rises dramatically in early pregnancy and has been linked to nausea, vomiting, and hyperemesis gravidarum (HG). Significant challenges remain as GDF15 levels overlap between normal and complicated pregnancies, limiting its current clinical utility as a biomarker. …

dk (code pays fourni par la source)

Arachidonoyl-taurine is elevated in human MASLD and protects against hepatic steatosis and inflammation in preclinical models

Katharina B. Kuentzel, Samuel A.J. Trammell, Anna S. Hassing, Ivan Bradić et autres

BACKGROUND & AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), represent a global health challenge intricately linked to lipid dysregulation and systemic inflammation. Identifying biomarkers and causative molecules involved in disease progression is therefore …

dk, gb, ca, us (code pays fourni par la source)

Omega-3 fatty acid supplementation improves skeletal muscle mitochondrial function in a model of Barth syndrome

Trisha J. Grevengoed, Nils Faergeman, Katharina Barbara Kuentzel

The composition of mitochondrial membrane lipids is crucial to cellular respiration, as seen in Barth syndrome (BTHS), a rare disease affecting skeletal muscle, heart, and neutrophils. In BTHS, mutations in the tafazzin (TAZ) gene reduce remodeling of the mitochondrial phospholipid, cardiolipin, resulting …

Omega-3 fatty acid supplementation improves skeletal muscle mitochondrial function in a model of Barth syndrome

Trisha J. Grevengoed, Nils Faergeman, Katharina Barbara Kuentzel

The composition of mitochondrial membrane lipids is crucial to cellular respiration, as seen in Barth syndrome (BTHS), a rare disease affecting skeletal muscle, heart, and neutrophils. In BTHS, mutations in the tafazzin (TAZ) gene reduce remodeling of the mitochondrial phospholipid, cardiolipin, resulting …