Henry Mauricio Chaparro-Solano

Placebo Effect in Levodopa‐Induced Dyskinesia: A Systematic Review and Meta‐Analysis

Luiz Vinicius Silva Correa, Alexandre Martins do Nascimento, Bruno Lopes Santos‐Lobato, Henry Mauricio Chaparro-Solano et autres

Abstract Background Levodopa‐induced dyskinesia (LID) is a complication of Parkinson's disease (PD) treatment. While the placebo effect is a known component in PD clinical trials, its specific magnitude in the context of LID is not well characterized. Objective To quantify the magnitude …

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Levodopa-Induced dyskinesia in Latin America: Prevalence and associated clinical factors in the LARGE-PD cohort

Henry Mauricio Chaparro-Solano, Daniel Teixeira-Dos-Santos, Emily Waldo, Thiago Peixoto Leal et autres

BackgroundAlthough levodopa is the gold standard treatment for Parkinson's disease (PD), its chronic use is associated with levodopa-induced dyskinesia (LID), a motor complication that impacts prognosis, quality of life, and treatment costs. Most known LID-associated factors have been identified in European-descendant populations.ObjectivesTo …

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Environmental Determinants of Parkinson’s Disease and Attributable Burden in Latin America: Findings from the LARGE-PD Consortium

Daniel Teixeira dos Santos, Henry Mauricio Chaparro-Solano, Felipe Duarte-Zambrano, Thiago Peixoto Leal et autres

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EPIDEMIOLOGY OF LEVODOPA-INDUCED DYSKINESIA: PREVALENCE AND ASSOCIATED CLINICAL FACTORS IN LATIN AMERICA

Henry Mauricio Chaparro-Solano, Daniel Teixeira dos Santos, Emily Waldo, Thiago Peixoto Leal et autres

Background: Although levodopa remains the gold standard treatment for Parkinson's disease (PD), its chronic use is associated with levodopa-induced dyskinesia (LID), a motor complication that impacts prognosis, quality of life, and treatment costs. Most known LID-associated factors have been identified in European-descendant …

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Genotype-phenotype association study conducted on LARGE-PD reveals novel loci associated with Parkinson’s Disease

Thiago Peixoto Leal, Emily Waldo, Felipe Duarte-Zambrano, Miguel Inca‐Martinez et autres

Abstract Background The Latin American Research Consortium on the Genetics of Parkinson’s Disease (LARGE-PD) is a multicenter collaboration aimed at understanding the genetic architecture of Parkinson’s disease (PD) in this underrepresented population using data from 15 countries across the Americas and the …

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Genetic Risk Factors in Normal Pressure Hydrocephalus: What We Know and What Is Next

Camila Piccinin, Saar Anis, Jeryl Ritzi T. Yu, Philippe A. Salles et autres

Knowledge of the genetic factors in normal pressure hydrocephalus (NPH) is rapidly evolving, with significant advances in recent years. We conducted a systematic review examining genetic contributions to NPH risk. Ovid Embase, Ovid Medline, Web of Science, and Cochrane Central were searched …

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Machine Learning approaches for predicting Levodopa-Induced Dyskinesias in Latino Populations

Henry Mauricio Chaparro-Solano, Miguel Inca‐Martinez, G. Alvarado, Sarael Alcauter et autres

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Authors' reply to “Comment on Chaparro-Solano et al.: ‘Critical evaluation of the current landscape of pharmacogenomics in Parkinson's disease – What is missing? A systematic review’”

Henry Mauricio Chaparro-Solano, Ignácio F. Mata

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Sex differences in the diagnosis latency of Parkinson's disease in Latin America

Janvi Ramchandra, Miguel Inca‐Martinez, Thiago Peixoto Leal, Henry Mauricio Chaparro-Solano et autres

BACKGROUND: Age and sex are known risk factors for Parkinson's Disease (PD), but it remains controversial if there are sex differences in the diagnosis latency. The objective of this study was to examine these sex differences in Latin America. METHODS: The Latin …

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Differences and contributors to global cognitive performance in the underrepresented Latinx Parkinson’s disease population

Saar Anis, Henry Mauricio Chaparro-Solano, Thiago Peixoto Leal, Scott A. Sperling et autres

Objective: Despite significant progress in understanding the factors influencing cognitive function in Parkinson’s disease (PD), there is a notable gap in data representation for the Latinx population. This study aims to evaluate the contributors to and disparities in cognitive performance among Latinx …

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Critical evaluation of the current landscape of pharmacogenomics in Parkinson's disease - What is missing? A systematic review

Henry Mauricio Chaparro-Solano, María Paz, Saar Anis, Jennifer Hockings et autres

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Genetic Screening in Patients with Parkinson Disease and Deep Brain Stimulation

Ekhlas Assaedi, Henry Mauricio Chaparro-Solano, Darlene Floden, Ignácio F. Mata et autres

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