Abstract 2425: Engineering SIRPα conformational plasticity to reveal a cryptic pocket suitable for structure-based drug design
Martin Storder, Florence Cordier, Sarah Barelier, Karine Barral et autres
Abstract The protein-protein interaction between Signal Regulatory Protein alpha (SIRPα) and CD47 is a critical immune checkpoint that enables tumor immune escape, making it a key target for cancer immunotherapy. While antibody-based therapies exist, the development of small-molecule inhibitors has been hindered …
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Cancer Research