Florence Cordier

Abstract 2425: Engineering SIRPα conformational plasticity to reveal a cryptic pocket suitable for structure-based drug design

Martin Storder, Florence Cordier, Sarah Barelier, Karine Barral et autres

Abstract The protein-protein interaction between Signal Regulatory Protein alpha (SIRPα) and CD47 is a critical immune checkpoint that enables tumor immune escape, making it a key target for cancer immunotherapy. While antibody-based therapies exist, the development of small-molecule inhibitors has been hindered …

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BPS2026 – Structural characterization of an adhesion GPCR disordered C terminal with AlphaFold

Margaux Héritier, Florence Cordier, Nicolas Wolff, Massimiliano Bonomi

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Engineering SIRPα conformational plasticity to reveal a cryptic pocket suitable for structure-based drug design

Martin Storder, Sarah Barelier, Florence Cordier, Taher Yacoub et autres

The protein-protein interaction between Signal Regulatory Protein alpha (SIRPα) and CD47 is a critical immune checkpoint that enables tumor immune escape, making it a key target for cancer immunotherapy. While antibody-based therapies exist, the development of small-molecule inhibitors has been hindered by …

fr, ch, us (code pays fourni par la source)

The SOFAST-HMBC-HMQC experiment for pairing geminal methyl groups in valine and leucine side-chains

Ana Paula Aguilar Alva, Lucas Siemons, Ulric B. le Paige, Coline Wiame et autres

fr, be (code pays fourni par la source)

The SOFAST-HMBC-HMQC experiment for pairing geminal methyl groups in Valine and Leucine side-chains.

Ana Paula Aguilar Alva, Lucas Siemons, Ulric le Paige, Coline Wiame et autres

Methyl groups are essential probes for characterising interactions and dynamics in large proteins. HN-based triple- resonance NMR experiments are often too insensitive for methyl assignments, making a NOESY-based approach an efficient strategy. Linking geminal methyl groups in leucine and valine residues is …

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Communication between DNA polymerases and Replication Protein A within the archaeal replisome

Markel Martínez‐Carranza, Léa Vialle, Clément Madru, Florence Cordier et autres

Replication Protein A (RPA) plays a pivotal role in DNA replication by coating and protecting exposed single-stranded DNA, and acting as a molecular hub that recruits additional replication factors. We demonstrate that archaeal RPA hosts a winged-helix domain (WH) that interacts with …

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The BEST-HMBC-HMQC experiment for pairing geminal methyl groups in Valine and Leucine side-chains.

Ana Paula Aguilar Alva, Lucas Siemons, Ulric le Paige, Coline Wiame et autres

Methyl groups are essential probes for characterising interactions and dynamics in large proteins. HN-based triple-resonance NMR experiments are often too insensitive for methyl assignments, making a NOESY-based approach an efficient strategy. Linking geminal methyl groups in leucine and valine residues is a …

fr, be (code pays fourni par la source)

Communication between DNA polymerases and Replication Protein A within the archaeal replisome

Markel Martínez‐Carranza, Léa Vialle, Clément Madru, Florence Cordier et autres

ABSTRACT Replication Protein A (RPA) plays a pivotal role in DNA replication by coating and protecting exposed single-stranded DNA, and acting as a molecular hub that recruits additional replication factors. We demonstrated that archaeal RPA hosts a winged-helix domain (WH) that interacts …

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Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system

Régine Dazzoni, Yuanyuan Li, Aracelys López‐Castilla, Sébastien Brier et autres

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Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system

Régine Dazzoni, Yuanyuan Li, Aracelys López‐Castilla, Sébastien Brier et autres

Abstract Type II secretion systems (T2SS) allow diderm bacteria to secrete hydrolytic enzymes, adhesins or toxins important for growth and virulence. In T2SS, secretion of folded proteins from the periplasm to the cell surface requires assembly of periplasmic filaments called pseudopili. Like …

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Deciphering the Molecular Interaction Between the Adhesion G Protein-Coupled Receptor ADGRV1 and its PDZ-Containing Regulator PDZD7

Baptiste Colcombet-Cazenave, Florence Cordier, Yanlei Zhu, Guillaume Bouvier et autres

Hearing relies on the transduction of sound-evoked vibrations into electrical signals, occurring in the stereocilia bundle of inner ear hair cells. The G protein-coupled receptor (GPCR) ADGRV1 and the multi-PDZ protein PDZD7 play a critical role in the formation and function of …

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H, 15 N and 13 C resonance assignments of the Cterminal domain of PulL, a component of the Klebsiella oxytoca type II secretion system

Régine Dazzoni, Aracelys López‐Castilla, Florence Cordier, Benjamin Bardiaux et autres

fr (code pays fourni par la source)