Accès ouvert
2026
article
OpenAlex
Zhengxian Fan, Qianqian Yang, Yu Hu, Goodarz Danaei et autres
Target trial emulation (TTE) is increasingly used for causal inference from observational data, but remains vulnerable to confounding by indication, and whether advanced adjustment methods mitigate this bias is unclear. Using Clinical Practice Research Datalink Aurum, we emulate target trials of beta-blockers …
gb, us
(code pays fourni par la source)
2026
preprint
OpenAlex
Shishir Rao, Marjan Walli-Attaei, Nouman Ahmed, Zhengxian Fan et autres
Abstract Background Current risk assessment tools for guiding direct oral anticoagulant (DOAC) therapy for patients with atrial fibrillation (AF) based on clinical risk factors demonstrate modest predictive performance limiting clinical impact. Additionally, while guidelines recommend periodic reassessment of risk over time, there …
gb
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Jie Lian, Zhengxian Fan, Ben Omega Petrazzini, Wei Fan et autres
Neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) are clinically heterogeneous, hampering the success of nonselective treatment strategies. Here we apply a transformer-based unsupervised clustering framework to longitudinal electronic health record data from over 100,000 patients across two UK …
gb
(code pays fourni par la source)