Accès ouvert
2026
article
OpenAlex
Tuyu Zheng, Sophie Cochiolo, Hua Sun, Alisha Kardian et autres
Abstract Neuronal regulation of pediatric brain tumors has emerged as an important contributor to cancer progression, yet tools to interrogate tumor-neuron interactions in native, developmentally accurate models remain limited. This has constrained our ability to understand how neural circuits engage tumors across …
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Accès ouvert
2026
article
OpenAlex
Siri Manasa Ippagunta, Amir Arabzade, Srinidhi Varadharajan, Erik Emanus et autres
BACKGROUND: Ependymoma (EPN) is the third most common pediatric brain tumor with no targeted therapies available to patients. In supratentorial ependymoma, the most frequent driver alteration is a gene fusion between ZFTA and RELA (denoted ZR), leads to constitutive localization of ZR …
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Accès ouvert
2026
article
OpenAlex
Alisha Kardian, Hua Sun, Siri Manasa Ippagunta, Nicholas Laboe et autres
ZFTA–RELA is the most recurrent genetic alteration seen in paediatric supratentorial ependymoma (EPN) and is sufficient to initiate tumours in mice1. Despite its oncogenic potential, ZFTA–RELA (ZR) is observed nearly exclusively in childhood EPN, with tumours located distinctly in the supratentorial brain …
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