Antitumor Cytisine-Platinum(IV) Prodrugs Potentiate Crosstalk between Endoplasmic Reticulum and Mitochondria through Calcium Overload Accompanied by Immunogenic Cell Death
Ruo-Xi Sang, Yang-Qi Wang, Xiu-Yuan Wu, Zhe Li et autres
Given the critical role of interorganellar communication in cancer malignancy, this study focuses on the regulatory mechanism of calcium signaling mediated by endoplasmic reticulum (ER)-mitochondria contacts in tumor cell apoptosis. A series of Pt(IV) prodrugs derivatives incorporating the natural compound cytisine (CYT) …
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