103P Time-dependent censoring imbalance and robustness of PFS and OS estimates in trials supporting EMA approval of first-line anti–PD-1/PD-L1 therapy for PD-L1–high advanced NSCLC
F. Vitale, S. D'Ambrosio, Annarita Avanzo, M.C. Isernia et autres
In first-line advanced non-small cell lung cancer (NSCLC) with PD-L1 ≥50%, immune checkpoint inhibitors (ICIs) improve progression-free survival (PFS) and overall survival (OS). Standard survival analyses assume non-informative censoring, an assumption that may be violated in open-label immunotherapy trials. We assessed the …
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