Accès ouvert
2026
preprint
OpenAlex
Justin Wagner, Ayse G. Keskus, Keisuke K. Oshima, T. Rhyker Ranallo-Benavidez et autres
Summary Cancer genome sequencing is essential for understanding tumor evolution and advancing precision medicine. 1 However, reference gaps and germline variants obscure detection of small and large somatic variants and methylation in repetitive regions. 1–3 It is common for tumor cells to …
us, sg, nl, se, au, hk
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2026
conference-abstract
OpenAlex
Jee Yun Han, Yash Patel, Paul Boutros, Jaron Arbet et autres
Abstract Cancer evolves under diverse selective pressures and is characterized by widespread dysregulation of gene expression. Transcriptomic studies have traditionally relied on differential expression analyses between predefined patient groups to identify genes associated with specific clinical or molecular phenotypes. However, cancers also …
us
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Accès ouvert
2026
article
OpenAlex
Yash Patel, Chenghao Zhu, Takafumi N. Yamaguchi, Nicholas K. Wang et autres
The price, quality, and throughput of DNA sequencing continue to improve. Algorithmic innovations have allowed inference of a growing range of features from DNA sequencing data, quantifying nuclear, mitochondrial, and evolutionary aspects of both germline and somatic genomes. To automate analyses of …
us
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