Copy Number-Based Oncogene Dominance May Suggest ERBB2 Dependence and Trastuzumab Response in HER2-Positive Gastric Cancer
Takeru Wakatsuki, Noriko Yamamoto, Naoki Ishizuka, Shuichi Hironaka et autres
BACKGROUND: While oncogene co-amplification is frequently observed, its clinical significance remains unclear, particularly with regard to its association with copy number. OBJECTIVE: The aim of this study was to elucidate the molecular traits of human epidermal growth factor receptor 2 (HER2)-positive gastric …
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Targeted Oncology