Hannah; id_orcid 0000-0002-2987-7936 Mitchell

Osr1-expressing mesoderm contributes to lymphatic vessel assembly and complexity in the mammalian kidney

Daniyal J. Jafree, Lauren G. Russell, Athanasia Stathopoulou, Charlotte O’Riordan et autres

Lymphatic vessels perform diverse functions, ranging from fluid homeostasis to immune regulation, and arise from multiple cellular origins to form organ-specific networks. Despite their importance in kidney disease and transplant immunity, the origins of kidney lymphatics are unknown. Using genetic lineage tracing …

gb, ca, us (code pays fourni par la source)

Proteomic biomarkers differentiate bacterial infections in febrile infants: A multicentre prospective study

Clare Mills, Holly Drummond, Narainrit Karuna, Hannah; id_orcid 0000-0002-2987-7936 Mitchell et autres

OBJECTIVES: To identify and validate plasma host-response protein biomarkers that improve discrimination of bacterial infection in febrile infants ≤90 days of age, and to assess whether novel biomarkers add value beyond established markers. METHODS: Sub-study of the prospective multicentre Febrile Infant Diagnostic …

gb, th (code pays fourni par la source)

Triple-stochastic models and palm-trees: spatial point processes in super-resolution data

Jack; id_orcid 0009-0001-1817-5402 Peyton, Benjamin J.K. Davis, Daniel J. Rolfe, Hannah; id_orcid 0000-0002-2987-7936 Mitchell

Recent advances in super-resolution fluorescence microscopy, such as MINFLUX, enable the localisation of single molecules with nanometre precision. These developments offer new opportunities to investigate molecular organisation at an unprecedented spatial scale. However, the increasing resolution of microscopy data introduces new challenges …

it (code pays fourni par la source)

MINFLUX - A microscopic spatial statistics problem

Jack; id_orcid 0009-0001-1817-5402 Peyton, Benjamin J.K. Davis, Daniel J. Rolfe, Hannah; id_orcid 0000-0002-2987-7936 Mitchell

MINFLUX (Minimal Photon Fluxes) is a cutting-edge super-resolution fluorescence microscopy technique that achieves <5nm precision in molecular localisation. By utilising a donut-shaped excitation beam and iteratively refining molecular position estimates, MINFLUX surpasses the resolution of conventional fluorescence microscopy techniques such as STORM …

it, us (code pays fourni par la source)

Tracks and traces: accelerating intensity track identification for FLImP super-resolution imaging

Emily; id_orcid 0009-0003-0317-5906 Gribbin, Benjamin J.K. Davis, Daniel J. Rolfe, Hannah; id_orcid 0000-0002-2987-7936 Mitchell

Lung cancer is one of the leading causes of cancer deaths globally, with Non-Small Cell Lung Cancer (NSCLC) accounting for over 80% of all lung cancer diagnoses (Cancer.net, 2024). NSCLC development is partly driven by mutations in Epidermal Growth Factor Receptors (EGFRs), …

it, us (code pays fourni par la source)

The diagnostic test accuracy of procalcitonin (PCT) and c-reactive protein (CRP) in the detection of bacterial infections in febrile infants less than 90 days of age: a systematic review and meta-analysis

Hannah; id_orcid 0000-0002-0792-5490 Norman-Bruce, Etimbuk Umana, Clare Mills, Hannah; id_orcid 0000-0002-2987-7936 Mitchell et autres

Backgrounds: Procalcitonin (PCT) and C-reactive protein (CRP) are widely used biomarkers in the assessment of febrile infants under 90 days of age. In Europe and the USA, PCT is typically favoured whereas CRP is favoured in the UK. The aim of this …