George Davey Smith

Antihypertensive Treatment and Risk of Metabolic Associated Fatty Liver Disease:A Drug-Target Mendelian Randomisation

Yifan Hu, Karl Smith-Byrne, Zeinab Bidel, Xiong Xiao et autres

Background: Metabolic dysfunction–associated fatty liver disease, conventionally known as non-alcoholic fatty liver disease (NAFLD), affects over a quarter of the global population and currently lacks approved pharmacological treatments. Recognising the central role of hypertension in metabolic diseases, we hypothesised that elevated blood …

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Revisiting the Links Between Asthma and the Psychosis Spectrum:shared molecular mechanisms

Christina Dardani, Jamie Robinson, Karoline Alexandra Havdahl, Lisa Darrous et autres

Background Epidemiological studies suggest associations of asthma with the psychosis spectrum (psychotic experiences, bipolar disorder, schizophrenia), but the mechanisms underlying these associations remain unclear. Methods We examined the relationship between asthma and psychosis-related outcomes using observational cohort, polygenic score, and Mendelian randomization …

Baseline levels of C-reactive protein (CRP) and the incidence and outcome of human sepsis

Fergus Hamilton, Jonathan Underwood, Daniel B. Rosoff, Thomas E. Woolley et autres

C-reactive protein (CRP) is an evolutionarily conserved acute phase reactant believed to be critical for survival against infection. As a function of this, it is well known that circulating CRP levels can provide a valuable clinical measure of acute inflammatory illness. However, …

Evaluating Confounding in Rare Variant Genome Wide Association Studies

Aimee Hanson, Gareth J Griffith, Si Fang, Neil M Davies et autres

The theorised risk that confounded rare variant associations will emerge from population-based genetic studies has not been investigated empirically. Using 306,991 sequenced exomes from the UK Biobank, we demonstrate that recent demography is poorly captured by common and rare variant principal components …

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42.Mendelian Randomization

Mark Gormley, Ben G Faber, George Davey Smith

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Assessment of nicotine replacement therapy for harm reduction in smokers: an n-of-1 study

Maddy Dyer, Chris Stone, Suzanne McDonald, James McGree et autres

Implementing Mendelian Randomization to assess foetal risk from intrauterine prescriptive drug exposure for the treatment of diabetes, hypertension and thyroid related conditions in pregnancy

Ciarrah-Jane Barry, Venexia Walker, Christy Burden, Karoline Alexandra Havdahl et autres

INTRODUCTION Pregnant women are excluded from clinical trials for ethical and practical reasons; thus little is known about the causal impact of intrauterine exposure of prescribed medications on the developing foetus. Yet many chronic conditions necessitate maternal prescriptive medication such as diabetes, …

The causal effect of educational attainment on Alzheimer’s disease: A two-sample Mendelian randomization study

Emma Anderson, Kaitlin H. Wade, Gibran Hemani, Jack Bowden et autres

Causal effects of body mass index on cardiac structure and function in young adults using Mendelian randomisation

Hannah Taylor, Kaitlin H. Wade, Chloe Park, Nicholas John Timpson et autres

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Additional file 1: of Genetics of depressive symptoms in adolescence

Hannah Sallis, Jonathan T Evans, Robyn E. Wootton, Eva Krapohl et autres

This file contains Additional materials and methods, Tables S1-S2 and Figs. S1-S3. (DOCX 0.99 mb)

Additional file 1: of Genetics of depressive symptoms in adolescence

Hannah Sallis, Jonathan T Evans, Robyn E. Wootton, Eva Krapohl et autres

This file contains Additional materials and methods, Tables S1-S2 and Figs. S1-S3. (DOCX 0.99 mb)

Additional file 1: of Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development

Evie Stergiakouli, George Davey Smith, Joanna Martin, David Skuse et autres

Additional note. Selection of SDQ-ADHD measures. Additional note. Meta-analysis of correlated test statistics from pathway analysis. Additional note. Additional references. Additional note. Web resources. Table S1. Descriptives of SDQ-ADHD and SCDC scores in ALSPAC. Table S2. Phenotypic correlations of SDQ-ADHD scores in …