Chandan Kumar-Sinha

Liquid Biopsy in Lung Cancer: Toward Non-invasive Precision Medicine

Radha Paturu, Somnath Mahapatra, Anya Chinnaiyan, Yuping Zhang et autres

Real-world experience of a pediatric precision oncology protocol utilizing paired somatic and germline sequencing at a single institution: Interim analysis.

Joshua Goldman, Malay Mody, Lucas Ebert, David A. Hanauer et autres

10008 Background: While most pediatric oncology patients are cured with upfront therapy, outcomes for patients with metastatic and relapsed/refractory disease remain poor. Salvage therapy is toxic and has marginal success rates, necessitating novel, personalized approaches. We established our pediatric precision oncology program …

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A 15-layer multi-omics analysis of gastric cancer ecotypes provides therapeutic insights

Yuefan Wang, Lindsey K. Olsen, Fenglong Jiao, Chenwei Wang et autres

Gastric cancer is marked by profound molecular and microenvironmental heterogeneity that limits therapeutic progress. Here, we present a 15-layer multi-omics atlas that integrates genomics, epigenomics, transcriptomics, proteomics, multiple post-translational modifications (PTMs), protein-protein interactions, metabolomics, and microbiome profiles from 159 primary gastric adenocarcinomas …

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Abstract 4949: High resolution spatial transcriptomics reveals dynamic remodeling of the tumor microenvironment during prostate cancer progression

Jiayi Zhou, Gabriel Cruz, Somnath Mahapatra, Radha Paturu et autres

Abstract Prostate cancer exhibits diverse cellular composition, and the interaction between the tumor epithelial and tumor microenvironment (TME) cell types plays a crucial role in disease progression. However, due to technical limitations, systematic characterization of microenvironmental influences on prostate cancer progression remains …

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705 Clinicopathological Characterization of Claudin 18.2-Positive Gastric Adenocarcinoma

Zemplen Pataki, Radha Paturu, Josh Sinha, Somnath Mahapatra et autres

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830 SDHB Expression Dynamics in Prostate Cancer Evolution and Impact on Clinical Outcomes

Somnath Mahapatra, Radha Paturu, Fan Yang, Xuhong Cao et autres

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PATH-02. Molecular characterization of brain tumors from stereotactic needle biopsy surgical waste

Jack Wadden, Tiffany Adam, Benison Lau, Rodrigo T. Cartaxo et autres

Abstract Background Stereotactic needle biopsies of brain tumors are often performed in midline or deep-seeded brain regions and are risky procedures, with additional samples for molecular diagnostics conferring additional morbidity risk. To address this issue, we investigated whether tumor DNA recovered from …

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Additional file 1: of Landscape of gene fusions in epithelial cancers: seq and ye shall find

Chandan Kumar-Sinha, Shanker Kalyana-Sundaram, Arul M. Chinnaiyan

Recurrent gene fusions in epithelial cancers. Summary of recurrent gene fusions in epithelial carcinoma across different tissues. a Gene fusions with common 5′ and 3′ genes. b Multiple 5′ partners with common 3′ genes. c Common 5′ gene partners with multiple 3′ …

Additional file 1: of Landscape of gene fusions in epithelial cancers: seq and ye shall find

Chandan Kumar-Sinha, Shanker Kalyana-Sundaram, Arul M. Chinnaiyan

Recurrent gene fusions in epithelial cancers. Summary of recurrent gene fusions in epithelial carcinoma across different tissues. a Gene fusions with common 5′ and 3′ genes. b Multiple 5′ partners with common 3′ genes. c Common 5′ gene partners with multiple 3′ …

Additional file 2: of Landscape of gene fusions in epithelial cancers: seq and ye shall find

Chandan Kumar-Sinha, Shanker Kalyana-Sundaram, Arul M. Chinnaiyan

Clinical trials involving gene fusions in epithelial cancers. (PDF 287 kb)

Additional file 2: of Landscape of gene fusions in epithelial cancers: seq and ye shall find

Chandan Kumar-Sinha, Shanker Kalyana-Sundaram, Arul M. Chinnaiyan

Clinical trials involving gene fusions in epithelial cancers. (PDF 287 kb)

The polycomb group protein EZH2 is involved in progression of prostate cancer

Sooryanarayana Varambally, Saravana M. Dhanasekaran, Ming Zhou, Terrence R. Barrette et autres

Abstract Prostate cancer is a leading cause of cancer-related death in males and is second only to lung cancer. Although effective surgical and radiation treatments exist for clinically localized prostate cancer, metastatic prostate cancer remains essentially incurable. Here we show, through gene …