Ablation of PKCα Phosphorylation by CRISPR-Cas9 Base Editing Rescues Heart Failure
Tomonori Tadokoro, Hui Li, Peiheng Gan, Zhisheng Xu et autres
BACKGROUND: The prevalence of heart failure is increasing globally, with poor prognosis, highlighting the need for novel therapeutic strategies. PKCα (protein kinase C alpha), encoded by PRKCA , plays a central role in heart failure pathogenesis. Phosphorylation of PKCα at threonine 497 …
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2 citations
Circulation Research