Hugh M. O'Neill

Activation dynamics of a water-soluble human mu-opioid receptor

Eugene Agyemang, Raegan Van Wirt, Calixte Walls, Thomas T. Joseph et autres

The mu-opioid receptor (MOR), a class A G protein-coupled receptor mediates opioid analgesia and remains a central target for pain therapeutics. While crystal structures of MOR exist, they provide limited insight into the receptor's dynamic conformational landscape underlying function. Here, we engineered …

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BPS2026 – Advances in biological and chemical deuteration for neutron scattering studies

Qiu Zhang, Honghai Zhang, Wellington Claiton Leite, Kevin Weiss et autres

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BPS2026 – Molecular mechanism of ERD14 liquid-liquid phase separation under stress-mimicking conditions

Hugh M. O'Neill, Alan C. Hicks, Qiu Zhang, Wellington Claiton Leite

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BPS2026 – Amphiphilic co-solvents alter lateral membrane organization

Luoxi Tan, Haden L. Scott, Micholas Dean Smith, Sai Venkatesh Pingali et autres

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BPS2026 – Biophysical characterization of SARS-CoV-2 nonstructural protein Nsp8 condensates

Sharique A. Khan, Wellington Claiton Leite, Jennifer L Warnock, Youngchang Kim et autres

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BPS2026 - Ascertaining contributions of H/D exchange versus hydration shell in the calculation of small angle neutron scattering profiles

Alan C. Hicks, Wellington Claiton Leite, Sai Venkatesh Pingali, Joseph Curtis et autres

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BPS2026 – Structural characterization of the SARS-CoV-2 replication and transcription complex

Jennifer L Warnock, Sharique A. Khan, Wellington Claiton Leite, Qiu Zhang et autres

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BPS2026 – Structural dynamics of the human mu-opioid receptor in a lipid-free environment

Eugene Agyemang, Thomas T. Joseph, Naresh C. Osti, Eugene Mamontov et autres

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