Xuedong Li

Design, synthesis, and biological evaluation of selective HDAC6 inhibitors featuring an N-benzyl-2-(aryl/heteroaryl)acetamide cap

Tingting Li, Lingfang Wei, He Shi, Wenying Yan et autres

cn (code pays fourni par la source)

Discovery and Evaluation of E0714 as an Antiepileptic Candidate: A Highly Subtype-Selective Kv7 Agonist within the Kv7 Family Designed Based on a Kv7.2-Specific Pocket

Kening Qiao, Weidong Zhao, Yawen Cao, Tingting Li et autres

Subtype selectivity is critical in drug development, since off-target effects can restrict clinical application. Kv7.2 is a key target for treating neuronal hyperexcitability disorders. Nonselective activation of Kv7 channels can cause multisystem effects and increase therapeutic risk. Through a detailed analysis of …

cn, cz (code pays fourni par la source)

In silico discovery and biological evaluation of a novel selective HDAC8 inhibitor featuring 1H-pyrazolo[3,4-b]pyridine scaffold

Wenying Yan, He Shi, Tingting Li, Yan Hong Huang Fu et autres

cn (code pays fourni par la source)

RadioPharm: the database of radiopharmaceuticals

Jie Liu, Xingang Liu, Y. F. Zhang, Xuedong Li et autres

Radiopharmaceuticals (RPs) have emerged as a promising group of therapeutic/diagnostic agents with tremendous pharmaceutical advantages and profitable market value. With the rapid advances in this direction, there is an increasing demand for a knowledge base providing RP-relevant data. However, no such database …

cn (code pays fourni par la source)