Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex
Sang Ho Kwon, Boyi Guo, Cindy Fang, Madhavi Tippani et autres
Summary The dorsolateral prefrontal cortex (dlPFC) is central to cognitive dysfunction in schizophrenia (SCZ), yet how molecular changes are organized across cortex remains unclear. Here, we applied complementary spatial transcriptomic approaches spanning laminar domains, microenvironments, and cell types in postmortem human dlPFC. …
us (code pays fourni par la source)
2 citations
bioRxiv (Cold Spring Harbor Laboratory)