Chang YU

Salvianic Acid A-Loaded Layered Double Hydroxide Nanosheets Boost T-Cell Infiltration through Tumor Vascular Normalization for Enhanced Immunotherapy

Yuxi Xiang, Junyu Tan, Yan Xicheng, Yunyun Wu et autres

Abstract Abnormal tumor vasculature impedes T-cell migration and compromises immunotherapy. Conventional anti-angiogenic strategies fail to restore the endothelial barrier and adhesion molecules. This limitation hinders long-term therapeutic benefits. Therefore, simultaneously restoring vascular function and activating immunity is essential. Herein, a pH-responsive, salvianic …

cn, de (code pays fourni par la source)

Spatially Decoupled Piezoelectric Hydrogel with Trauma-Driven Migration of Engineered Platelets for Divergent Mitochondrial Fate Programming in Postoperative Cancer Therapy

Lei Liu, Daqing Xia, Yang Yang, Lunli Xiang et autres

Abstract Postoperative recurrence and metastasis remain major obstacles in solid tumor therapy because surgical intervention creates a spatially conflicting microenvironment. Here, a spatially decoupled piezoelectric hydrogel (BP@Gel) was developed to enable spatially divergent mitochondrial fate programming across the tumor-surgical-margin interface. Engineered platelets …

cn (code pays fourni par la source)

QF-DWPA: Quantile Feature With Dynamic Windowed Positional Attention for Hard Landing Prediction

Bokun Chu, Tianqi Chen, Yaotian Jiao, Chang YU et autres

cn (code pays fourni par la source)

Mechanistic Study of Astragaloside IV on Intestinal Barrier Function in Colitis Mice Through AhR/IL-22 Signaling Pathway

Jie ZHOU, Xüxia Ren, Yan Su, Youqing Dong et autres

Objective: To investigate the effects of Astragaloside IV (AS-IV) on intestinal barrier function in mice with ulcerative colitis (UC) and to explore its underlying mechanisms. Methods: The UC mouse model was established using 3% dextran sulfate sodium (DSS). Upon successful model establishment, …

cn (code pays fourni par la source)