Dapansutrile Mitigates DHT-Induced Polycystic Ovary Syndrome by Suppressing NLRP3 Inflammasome and TLR4/NF-κB Signaling
Bakiye Akbaş, Gülseren Dinç, Ahmet Akbaş, Gulcin Ercan et autres
This study investigated the therapeutic effects of Dapansutrile, a selective NLRP3 inflammasome inhibitor, on ovarian dysfunction in a dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS) rat model. Thirty adult female Wistar rats were allocated to control, PCOS + saline, and PCOS + Dapansutrile …
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