Degraders of the dengue virus capsid protein exhibit differentiated pharmacology relative to capsid inhibitors
Antara Chakravarty, Lu-Ning Wang, Ryan P. Golden, Zhengnian Li et autres
Abstract Due to the limited size of viral genomes, most viral proteins are multifunctional; yet most direct-acting antivirals are designed as single-function inhibitors. The dengue virus (DENV) capsid protein serves as a building block for new virions while also interacting with multiple …
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Nature Communications