Maria Eugenia Marques da Costa

Engineered flavonoid disrupts mitochondrial AIF/CHCHD4 complex for targeted cancer therapy.

Hong Toan Lai, Daniela Dias‐Pedroso, Maria Eugenia Marques da Costa, Romain Fernandes et autres

fr, pt (code pays fourni par la source)

Combined inhibition of AIF/CHCHD4 interaction and GLS1 to exploit metabolic vulnerabilities in pediatric osteosarcoma

Catherine BRENNER, Hong-Toan Lai, Tran Ngoc Anh Nguyen, Maria Eugenia Marques da Costa et autres

fr (code pays fourni par la source)

Combined inhibition of AIF/CHCHD4 interaction and GLS1 to exploit metabolic vulnerabilities in pediatric osteosarcoma

Hong-Toan Lai, Tran Ngoc Anh Nguyen, Maria Eugenia Marques da Costa, Romain Fernandes et autres

Abstract Osteosarcoma is a malignant bone tumor with a high risk of metastatic relapse and poor outcomes due to primary and acquired chemoresistance. This highlights the medical need to develop effective targeted approaches to overcome chemoresistance. Recent studies have revealed the roles …

fr (code pays fourni par la source)

Abstract 6170: Development and characterization of 3D osteosarcoma models recapitulating tumor heterogeneity and bone microenvironment

Margaux Chantoiseau, Pierre Khneisser, Birgit Geoerger, N. Gaspar et autres

Abstract Introduction: Osteosarcoma is the most common primary bone cancer in adolescents and young adults. It is characterized by high heterogeneity and a hostile bone microenvironment shaped by osteoclasts, endothelial cells, and immunosuppressive myeloid populations, underscoring the need for innovative models to …

fr (code pays fourni par la source)

The ITCC-P4 PDX platform of pediatric cancers for preclinical testing

Aniello Federico, Apurva Gopisetty, Didier Surdez, Yasmine Iddir et autres

Abstract Cancer is the leading cause of disease-related deaths among children in high-income countries. Tumor heterogeneity and lack of mechanism-of-action-based therapeutic options are key challenges to overcome in order to improve pediatric cancer patients’ survival. Here, we report the EU-IMI-2 funded public-private …

de, fr, ch, nl, gb, us, at, sg, kr, br, es, cz, au, it (code pays fourni par la source)