ATP7B-maintained copper stores in myeloid progenitors are required for functional maturation of neutrophils
Som Dev, Yu Fei Wang, Moonjung Jung, Yingze Ma et autres
Copper (Cu) is essential for innate immunity; however, how neutrophils regulate Cu homeostasis to support their functions remains unclear. We found that myeloid progenitors express abundant Cu-transporter ATP7B targeted to distinct vesicles and store Cu in vesicles. During neutrophil differentiation, ATP7B is …
us, in (code pays fourni par la source)
0 citations
Cell Reports