Mitchell S. Cairo

Multimodal analysis of CD38 in T-cell Acute Lymphoblastic Leukemia Identifies Combinatorial Therapeutic Strategies

Rawan Shraim, Gongping Shi, Yizhen Li, Jason Xu et autres

Outcomes for pediatric patients with refractory or relapsed T-cell acute lymphoblastic leukemia (T-ALL) are poor, underscoring the need for improved therapeutic strategies. CD38, a type II transmembrane glycoprotein, is a promising target in T-ALL, with clinical trials evaluating CD38-targeting immunotherapies in frontline …

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Immune checkpoint therapy in pediatric and adolescent lymphomas

David J. Hoogstra, Ana C. Xavier, Paul Harker-Murray, Sarah Alexander et autres

Immune checkpoint therapy (ICT) is designed to unleash the anti-tumor activity of Tlymphocytes. Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) inhibition and programmed death 1 (PD-1) inhibition are the most commonly utilized ICTs in clinical cancer therapy, and they enhance anti-tumor immunity by interrupting …

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Targeting Acute Myeloid Leukemia By IL-1RAP.CAR NK Cells with or without NKTR-255 or Cam161533 Tri-Specific Killer Cell Engager (TriKE)

Shaimaa AbdAllah, Meijuan Tian, Mishel Ramirez, Wen Luo et autres

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Amplifying Allogeneic T cell Antitumor Responses in Pediatric Solid Tumors

Nicolas Jose Llosa, Aditya Suru, Kaushal Sharma, Julia I Nowik et autres

A Phase 1 Trial of Targeted Immunotherapy with Daratumumab Following Myeloablative Total Body Irradiation (TBI)-Based Conditioning and Allogeneic Hematopoietic Cell Transplantation (HCT) in Children, Adolescents and Young Adults with High-Risk T-cell Acute Lymphoblastic Leukemia and Lymphoma (T-ALL/T-LLy) (ALLO-T-DART): A Ptctc-Facilitated Study

Troy C. Quigg, Allyson M. Flower, David T. Teachey, Megan Lim et autres

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Targeting Ewing Sarcoma By ROR1 CAR CXCR2 NK Cells Combined with CamB7-H3 Tri-Specific Killer Engager and Anti-GD2 Antibody

Wen Luo, Hongwen Zhu, Yvette Soignier, Martin Felices et autres

Introduction Patients diagnosed with metastatic Ewing sarcoma (ES) have a dismal outcome. Lines of evidence have shown the importance of NK cell immunity against ES [1]. However, NK cell number and function are low in ES patients, in large part due to …

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Ex Vivo Expanded Mcam CAR NK Cells in Combination with Anti-GD2 Antibody Significantly Reduced Tumor Growth in Osteosarcoma Xenograft Model

Hongwen Zhu, Wen Luo, Mitchell S. Cairo, Joseph R. Caporale et autres

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Safety and Tolerability of Myeloablative Conditioning and Autologous Stem Cell Transplantation Followed By Polatuzumab Vedotin in B-cell Non-Hodgkin Lymphoma

Kayleigh Klose, Allyson M. Flower, Jessica C. Hochberg, Jaclyn Basso et autres

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Genomic and Immunomic Characterization, Safety and Efficacy of Related Donor-Derived Cytotoxic T-Lymphocytes (CTLs) in Immunocompromised Recipients with Medically Refractory Adv and CMV Infection: On Behalf of the Viral CTL Consortium (VIRCTLC)

Mitchell S. Cairo, Dean Anthony Lee, Laura J. Vella, Yanling Liao et autres