Cristina Muresan

Mean Arterial Pressure Dynamics Under Norepinephrine, Propofol and Remifentanil Drug Interactions: A PK/PD Validation Study in General Anesthesia

Isabela Birs, Marcian Mihai, Erwin Hegedüs, Vlad Dumitrescu et autres

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Systemic fragility in European total intravenous anesthesia delivery and opportunities for resilient real-time decision support

Clara Mihaela Ionescu, Erhan Yumuk, Michele Schiavo, Antonio Visioli et autres

Total intravenous anesthesia (TIVA) is a well-established technique for general anesthesia and is increasingly relevant to Europe’s transition toward more digital, sustainable, and patient-centred healthcare. However, its use remains uneven across centres and still depends heavily on population-based drug models, variable monitoring …

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A Robust $[\text{FO}-\text{PID}]^{\lambda}$ Controller for Computer-Controlled Chemotherapy

Nicoleta Badau, Cristina Muresan, Erhan Yumuk

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Fisher Information-Based Subspace Projection for Stable Online Pharmacodynamic Parameter Estimation in Dual-Drug Anesthesia

Erwin Hegedüs, Isabela Birs, Bouchra Khoumeri, Dana Copoţ et autres

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Event-based fractional order control for multi-drug anesthesia systems: Improved performance with computational efficiency

Erwin Hegedüs, Isabela Birs, Clara IONESCU, Marcian D. Mihai et autres

Automated multi-drug anesthesia presents a significant control challenge due to complex drug interactions and the need for high-reliability, resource-efficient systems. This paper introduces a novel event-based fractional order control framework that, contrary to conventional expectations, achieves improved control performance while simultaneously reducing …

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Fractional-order Model Predictive Control Design for Anesthesia–Hemodynamic stabilization During Surgical Procedures

Nesrine Izemrane, Samir LADACI, Erwin T. Hegedüs, Cristina Muresan

Delivering safe, patient-specific anesthesia demands simultaneous regulation of general-anesthesia and hemodynamic. This study proposes a steady state decoupled Fractional-Order Model Predictive Control (FOMPC) design of hemodynamic system under general anesthesia conditions particularly for patients during surgical procedures. We used a patient numerical …

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