Dawei Chen

Hepatoprotective Effects of Combined Inulin-Glucomannan Non-Starch Polysaccharide Against Western Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease

I Gede Putu Adhi Wedharga, M. Dimas Ananda, Nadilla Faiza Richadini, Bernadette Dian Novita et autres

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Fc-dependent and -independent Platelet Clearance Caused by Anti-CD36 IgG1 and IgG2 Subclasses

Hui Ren, Dawei Chen, Yalin Luo, Xiuzhang Xu et autres

Abstract Anti-CD36 isoantibodies can induce platelet transfusion refractoriness and fetal neonatal immune thrombocytopenia. However, the mechanism of platelet clearance mediated by these antibodies (Abs) in such disorders remains unknown. We analyzed platelet clearance caused by mouse and human CD36 monoclonal Abs GZ1 …

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Murine transfusion-related acute lung injury caused by anti-CD36 antibodies: mechanism and intervention

Dawei Chen, Justus Liebig University Giessen

Individuals lacking CD36 on both platelets and monocytes (type I) are at risk of developing anti-CD36 antibodies after receiving a platelet transfusion or during pregnancy. Anti-CD36 antibodies have been suggested to induce transfusion-related acute lung injury (TRALI) upon blood transfusion, particularly in …