Giulia Russo

Mechanistically Informed Prioritization of RNA–LNP Therapeutics: a Safety-by- Design Framework Integrating Virtual Patients, Synthetic Multi-Omics and Biological Consistency Assessment

Valentina Di Salvatore, Giulia Russo, Francesco Pappalardo

it (code pays fourni par la source)

Integrative agent-based modeling of cutaneous lupus: single-cell benchmarking and in silico evaluation of B-cell therapies

Abdul Wahab, Giulia Russo, Francesco Pappalardo

Agent-based models (ABMs) offer a powerful framework for representing emergent immune dynamics, yet their integration with single-cell datasets and therapeutics simulation remains limited. Here, we presented an integrative, single-cell informed systems immunology modeling framework built on universal immune system simulator (UISS) to …

it (code pays fourni par la source)

NX210c Demonstrates Therapeutic Potential to Restore Blood–Brain Barrier in a QSP Model of Relapsing–Remitting Multiple Sclerosis

Giulia Russo, Fianne L. P. Sips, Simona Catozzi, Pauline Bambury et autres

Blood-brain barrier (BBB) breakdown is a hallmark of several neurological disorders, including multiple sclerosis (MS). NX210c, a novel therapeutic peptide, has shown promise in restoring BBB integrity, in both preclinical and clinical settings, offering potential for use in MS populations and across …

it, nl, fr (code pays fourni par la source)