Pain signaling via sensory neurons drives breast cancer progression through neuropeptide release and κ-opioid counter-regulation
Hitoshi Makabe, Michiko Narita, Yasuyuki Nagumo, Masanori Fujiwara et autres
Severe pain in patients with breast cancer is associated with poorer survival outcomes, yet the mechanisms linking nociceptive signaling to tumor progression remain unclear. In a clinical cohort, breast cancer patients whose moderate or severe pain improved under specialized palliative care exhibited …
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