Identification of G-Quadruplexes in Hepatitis E Virus Negative-Sense Genomic RNA as Potent Antiviral Targets
Xiaohui Ding, Dou Zeng, Yingying Bian, Dan Liu et autres
Hepatitis E virus (HEV) causes significant global disease burden with no approved targeted therapies, highlighting the urgent need for innovative treatment strategies. G-quadruplexes (G4s), noncanonical nucleic acid structures formed by guanine-rich sequences, have emerged as important regulators of viral replication. Here, we …
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ACS Infectious Diseases