Real-world survival and responses to HER2 directed treatment in gastrointestinal cancers based on HER2 non-amplified mutation and HER2 amplification/overexpression status.
Nicole Balmaceda, Vida Alami, Junxiao Hu, Mihika Devireddy et autres
307 Background: Human epidermal growth factor receptor 2 (HER2) plays a vital role in cell proliferation, apoptosis, and ultimately tumorigenesis. HER2 targeted treatment (HER2 tx) has improved survival for patients with HER2 amplified tumors; however, its role in HER2 nonamplified mutated GI …
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Journal of Clinical Oncology