Anne Dunlop

Impact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopment

Patricia A. Brennan, Anne Dunlop, T.Q. Huynh, Kaitlin R. Taibl et autres

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Abstract MPWE26: Breastfeeding and Early Childhood Cardiovascular Health in the ECHO Program

McKenzie Jancsura, Jiqiang Wu, Izzuddin Aris, William Grobman et autres

Background: Breastfeeding is linked with single indicators of maternal and child cardiovascular health (CVH), but its association with comprehensive childhood CVH as defined by AHA Life’s Essential 8 (LE8) criteria is unclear. We investigated whether breastfeeding duration and exclusivity were associated with …

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Abstract 37: Associations of Prenatal Per- and Polyfluoroalkyl Substances (PFAS) Exposures and Childhood Blood Pressure in the Environmental influences on Child Health Outcomes (ECHO) Cohort

Frances Wang, Pi-i Lin, Izzuddin Aris, Theresa Bastain et autres

Background: PFAS are widespread, persistent chemicals that cross the placenta and may affect fetal development. Animal studies suggest prenatal PFAS exposure increases offspring blood pressure (BP); however, epidemiologic evidence is limited and inconsistent. Hypothesis: We hypothesized that prenatal PFAS exposure is associated …

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Evaluating Methods for High-Dimensional Mediation in Metabolomics Data

Susan Hoffman, Donghai Liang, Anne Dunlop, Todd M. Everson et autres

This study evaluated high-dimensional mediation analysis methods (HIMA by Zheng et al. and HDMA by Gao et al.) and the "Meet-in-the-Middle" (MITM) approach using simulated metabolomics data. Simulations varied in sample size, mediator set size, correlation structure, proportion of true mediators, and …

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