Sisse Rye Ostrowski

Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma

Maria Gluud, Emil M.H. Pallesen, Ziao Zeng, Martin R.J. Namini et autres

BACKGROUND: Skin barrier dysfunction is central to inflammation and susceptibility to infection in atopic dermatitis (AD). Cutaneous T-cell lymphoma (CTCL) shares clinical similarities with AD and is also associated with a high prevalence of Staphylococcus aureus (S. aureus) colonisation. However, the mechanisms …

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Interleukin-15 and innate effector cells as predictors of outcome in allogeneic hematopoietic cell transplantation

Marie Warny, Sisse Rye Ostrowski, Søren Lykke Petersen, Lone Smidstrup Friis et autres

Introduction: Immune reconstitution is a critical parameter in successful hematopoietic cell transplantation (HCT) and involves different cell types and a microenvironment including cytokines. Natural killer (NK) cells and γδ T cells are known to repopulate early after HCT and are proposed to …

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Large-Scale Proteomic Profiling of Incident Heart Failure and Its Subtypes in Older Adults

Joyce Njoroge, Sandra Sanders van Wijk, Thomas R. Austin, Jennifer A. Brody et autres

BACKGROUND: Heart failure (HF) and its main subtypes, heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF), impose an enormous health burden on elders. Assessment of the circulating proteome to illuminate pathogenesis could open new opportunities …

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Development and validation of a neural network survival prediction model for ischemic heart disease

Peter C. Holm, Amalie D. Haue, David Westergaard, Timo Röder et autres

BACKGROUND: Current risk prediction models for ischemic heart disease in clinical use are relatively simple and use a limited collection of well-known risk factors. Using machine learning to integrate a broader panel of features from electronic health records (EHRs) may improve post-angiography …

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Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants

Geller Frank, Xiaoping Wu, Vilma Lammi, Erik Abner et autres

The host genetics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have previously been studied based on cases from the earlier waves of the pandemic in 2020 and 2021, identifying 51 genomic loci associated with infection and/or severity. SARS-CoV-2 has shown rapid …

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Epidemiological and genetic evidence for shared mechanisms between migraine and pre-eclampsia: a nationwide cohort and genetic risk study in Denmark

Olafur B. Davidsson, Klaus Rostgaard, Ragnar P. Kristjansson, Jojo Biel-Nielsen Dietz et autres

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