Accès ouvert
2026
article
OpenAlex
Luís Henrique Corrêa, Heloísa Antoniella Braz-de-Melo, Igor de Oliveira Santos, Sarah Pinho Bezerra et autres
BACKGROUND: Adipose tissue metabolic plasticity and inflammation critically influence tumor progression through endocrine signaling. While white adipose tissue (WAT) has been linked to pro-tumorigenic effects in obesity-related cancers, the influence of brown adipose tissue (BAT) and its secretome on breast cancer remains …
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Accès ouvert
2026
article
OpenAlex
Gabriel Pasquarelli-do-Nascimento, Sarah Pinho Bezerra, Júlia Perin Manchine, Nathalia Cristina Silva Lago et autres
Ovarian cancer remains one of the most lethal gynecologic malignancies due to late diagnosis, limited treatment options, and frequent chemoresistance. Docosahexaenoic acid (DHA), a long-chain omega-3 polyunsaturated fatty acid, has been associated with anti-tumor effects in various cancer models. Here, we investigated …
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Accès ouvert
2026
article
OpenAlex
Heloísa Antoniella Braz-de-Melo, Fernanda Gomes Lago, Rafael Corrêa, Igor de Oliveira Santos et autres
Microglial cells exhibit crucial metabolic adaptations to maintain neural homeostasis. However, their dysregulated activation during infections can lead to neurotoxicity and contribute to the development of neuroinflammatory disorders. Understanding the physiological and metabolic changes of microglia during immune activation is crucial for …
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