Yuanzhong Yang

Primary renal synovial sarcoma: a clinicopathological study of 23 cases highlighting the diagnostic value of SS18-SSX, TLE1, and INI1 immunohistochemistry panel

Yuanzhong Yang, Jiayu Wang, Ya Chen, Hongtao Jin et autres

cn (code pays fourni par la source)

Multi-omics profiling identifies HMGA2 fusions as defining a distinct and prognostically favorable subtype of dedifferentiated liposarcoma with rhabdomyosarcomatous differentiation

Xinke Zhang, Xiujiao Shen, P Chen, Xinyi Xian et autres

cn (code pays fourni par la source)

Author Correction: A proteogenomic atlas of 1032 brain metastases identifies molecular subtypes, immune landscapes, and therapeutic vulnerabilities

Zhenyu Yang, Shiyou Wei, Hao Bo Duan, Xiuqi Wang et autres

In the Acknowledgements section of this article the grant number relating to Science and Technology Support Program of Sichuan Province given for Shiyou Wei was incorrectly given as “2023YFS0126 and 2023NSFSC0732” and should have been “2023YFS0126”. The original article has been corrected.

cn, hk (code pays fourni par la source)

A longitudinal, multi-omic atlas reveals the emergence of a spatially organized immunosuppressive ecosystem in resistant melanoma

Shiyou Wei, Yulan Deng, Jinho Lee, Hongbin Lan et autres

Despite advances in immune checkpoint blockade, resistance in metastatic melanoma remains a major challenge. To decode resistance mechanisms, we generate a comprehensive longitudinal, multi-omic, and spatial atlas of 45 tumor samples across 10 patients. Analysis reveals resistant tumors undergo convergent evolution toward …

cn, us, hk, ca, nl, jp (code pays fourni par la source)

A proteogenomic atlas of 1032 brain metastases identifies molecular subtypes, immune landscapes, and therapeutic vulnerabilities

Zhenyu Yang, Shiyou Wei, Hao Duan, Xiuqi Wang et autres

The molecular heterogeneity of brain metastases hampers therapeutic development for cures. To address this unmet and urgent need, we construct a comprehensive multi-omic, single cell, and spatially resolved atlas of 1,032 pan-cancer brain metastases, identifying four robust molecular subtypes with distinct biological …

cn, hk (code pays fourni par la source)

The BRAF V600E/MEK/ERK/METTL3 positive feedback loop regulates autophagy and promotes stemness and invasiveness in glioblastoma via m6A modification

Yuan Xie, Yan Li, Meiqin Tang, Zhi Li et autres

Abstract Background Epithelioid glioblastoma (GBM) is characterized by its highly aggressive behavior and the presence of the BRAF V600E mutation. However, the impact and underlying mechanisms of the BRAF V600E mutation on GBM stemness and invasiveness are unknown. Dysregulation of N6-methyladenosine (m6A) …

cn (code pays fourni par la source)

The BRAF V600E/MEK/ERK/METTL3 positive feedback loop regulates autophagy and promotes stemness and invasiveness in glioblastoma via m6A modification

Yuan Xie, Yan Li, Meiqin Tang, Zhi Li et autres

Abstract Background Epithelioid glioblastoma (GBM) is characterized by its highly aggressive behavior and the presence of the BRAF V600E mutation. However, the impact and underlying mechanisms of the BRAF V600E mutation on GBM stemness and invasiveness are unknown. Dysregulation of N6-methyladenosine (m6A) …

cn (code pays fourni par la source)

Additional file 1 of The BRAF V600E/MEK/ERK/METTL3 positive feedback loop regulates autophagy and promotes stemness and invasiveness in glioblastoma via m6A modification

Yuan Xie, Yan Li, Meiqin Tang, Zhi Li et autres

Supplementary Material 1.

cn (code pays fourni par la source)

Additional file 1 of The BRAF V600E/MEK/ERK/METTL3 positive feedback loop regulates autophagy and promotes stemness and invasiveness in glioblastoma via m6A modification

Yuan Xie, Yan Li, Meiqin Tang, Zhi Li et autres

Supplementary Material 1.

cn (code pays fourni par la source)

The BRAF V600E/MEK/ERK/METTL3 positive feedback loop regulates autophagy and promotes stemness and invasiveness in glioblastoma via m6A modification

Yuan Xie, Yan Li, Meiqin Tang, Z Z Li et autres

BACKGROUND: Epithelioid glioblastoma (GBM) is characterized by its highly aggressive behavior and the presence of the BRAF V600E mutation. However, the impact and underlying mechanisms of the BRAF V600E mutation on GBM stemness and invasiveness are unknown. Dysregulation of N6-methyladenosine (m6A) modification …

cn (code pays fourni par la source)