Accès ouvert
2026
preprint
OpenAlex
Matthew Burnell, Jennifer Nicholas, Rachel Burton, Sean Apap Mangion et autres
Abstract Background Interim stage outcomes in multi-arm multi-stage trials need not be the same as the final primary outcome, and should be selected with the goal of providing the best chance of continuing with an effective treatment in the study during the …
gb
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Sean Apap Mangion, Charles Wade, Cheryl Pugh, Matthew Burnell et autres
ABSTRACT Introduction Current treatments for multiple sclerosis (MS) do not address the pathological processes of neurodegeneration and chronic demyelination. This, coupled with the significant challenges of translating promising phase 2 results to phase 3 trial success, highlights the need for more efficient …
gb, us, au, nl
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Stefan Witek-McManus, Nozgechi Phiri, James R. Carpenter, Shekinah Munthali-Mkandawire et autres
1. ABSTRACT Background Excess dietary salt intake and high blood pressure are growing public health challenges in Africa, with limited evidence for effective interventions. We evaluated the effect of a school-based programme on salt intake and blood pressure of adolescents and their …
gb, Malawi
(code pays fourni par la source)