Accès ouvert
2025
article
OpenAlex
Richard Sherva, Henry Bayly, Rui Zhang, Jesse Mez et autres
Abstract Background As biobank‐scale cohorts emerge, there has been a great increase in the number of dementia cases available for genetic meta‐analyses, resulting in a substantial increase in the number of dementia risk variants identified and replicated. Although also increasing, the number …
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Accès ouvert
2025
article
OpenAlex
Jesse Mez, Brigid Dwyer, Michael L. Alosco, Belinda Yew et autres
BACKGROUND: Validity of the 2021 NINDS Traumatic Encephalopathy Syndrome (TES) criteria, proposed to diagnose chronic traumatic encephalopathy (CTE) in life, has not been assessed. METHODS: Brain donors were selected across 6 brain banks (15+ donors each), 9 repetitive head impact (RHI)/traumatic brain …
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Accès ouvert
2025
article
OpenAlex
Marlene Tejeda, John J. Farrell, Congcong Zhu, Lee M. Wetzler et autres
Abstract Background Several viruses, including HSV‐1, can establish latent infections in neurons and have been linked to Alzheimer disease (AD). Method Whole genome sequence reads derived from brain (561 AD cases, 259 controls) and blood (5,033 AD cases, 4,907 controls) specimens obtained …
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Accès ouvert
2025
article
OpenAlex
Alexandra N. Regelson, Derek B. Archer, Alaina Durant, Shubhabrata Mukherjee et autres
BACKGROUND: Despite evidence that Alzheimer's Disease (AD) is a highly heritable disease, there remains substantial "missing" heritability, likely due to the clinical and neuropathologic heterogeneity inherent in the disease. Here, we leverage sensitive longitudinal cognitive measures as endophenotypes in a rare variant …
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Accès ouvert
2025
article
OpenAlex
Alaina Durant, Shubhabrata Mukherjee, Michael L. Lee, Seo‐Eun Choi et autres
BACKGROUND: "SuperAgers" are oldest-old adults (ages 80+) with memory performance resembling adults in their 50s to mid-60s. This study assessed presence and levels of Alzheimer's disease (AD) neuropathologic change (ADNC) and concomitant neuropathologies in SuperAgers, AD cases, and oldest-old controls using three …
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