Accès ouvert
2026
article
OpenAlex
Prashanthi Vemuri, Mingzhao Hu, Emily S. Lundt, Michael G. Kamykowski et autres
BACKGROUND: White matter hyperintensities (WMH) are widely used to assess cerebral small vessel disease but reflect late-stage injury. Diffusion magnetic resonance imaging (MRI) biomarkers have been proposed to capture earlier small vessel disease-related microstructural damage but their temporal progression relative to WMH …
us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Mingzhao Hu, David S. Knopman, Terry Therneau, Angela J. Fought et autres
INTRODUCTION: We examined when Alzheimer's disease biomarkers become informative by identifying age-related breakpoints with slope-changing trajectories. METHODS: In 2082 Mayo Clinic Study of Aging participants, we modeled plasma amyloid beta (Aβ)42/40, phosphorylated tau (p-tau)181, glial fibrillary acidic protein (GFAP), neurofilament light chain …
us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Petrice M. Cogswell, Emily S. Lundt, Terry M. Therneau, Mingzhao Hu et autres
Associations of Alzheimer's disease biomarker progression with cognitive decline are important to inform patient prognosis. Of particular interest is how newly available plasma biomarkers evolve relative to cognitive decline. The goals of this work are to measure how much earlier versus later …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Calvin D. Reyes, Robel K Gebre, Jeffrey L. Gunter, Mingzhao Hu et autres
Abstract Background Multi‐site aging and dementia studies are challenged by data heterogeneity caused by scanner (manufacturer and protocol) related variability. Quantitative analysis of white matter hyperintensity (WMH) from pooled samples, a traditional marker of cerebrovascular disease, is sensitive to machine variability. Our …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Mingzhao Hu
BACKGROUND: Despite advances in Alzheimer's disease (AD) research, limited information exists regarding the absolute risk of mild cognitive impairment (MCI) in cognitively unimpaired (CU) individuals with abnormal AD biomarkers, particularly when accounting for competing risks of death. This knowledge gap is critical …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Mingzhao Hu
BACKGROUND: Cerebrovascular disease (CeVD), a common co-pathology with Alzheimer's Disease, has not been sufficiently operationalized, limiting its usage for accurate estimation of vascular contributions to cognitive impairment (VCI). The proposed CeVD biomarker classification uses more recently developed diffusion MRI markers (fractional anisotropy …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Xi Yu, Mingzhao Hu, Scott A. Przybelski, Robert I. Reid et autres
BACKGROUND: Chronic disease conditions lead to brain changes elevating dementia risk. We hypothesized that tissue microstructural changes caused by type 2 diabetes mellitus (T2DM) and hypertension could be effectively captured using an advanced diffusion MRI technique, Neurite Orientation Dispersion and Density Imaging …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Mingzhao Hu
BACKGROUND: Cerebrovascular disease (CeVD), a common co-pathology with Alzheimer's Disease, has not been sufficiently operationalized, limiting its usage for accurate estimation of vascular contributions to cognitive impairment (VCI). The proposed CeVD biomarker classification uses more recently developed diffusion MRI markers (fractional anisotropy …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Mingzhao Hu
Abstract Background Despite advances in Alzheimer's disease (AD) research, limited information exists regarding the absolute risk of mild cognitive impairment (MCI) in cognitively unimpaired (CU) individuals with abnormal AD biomarkers, particularly when accounting for competing risks of death. This knowledge gap is …
us
(code pays fourni par la source)