Accès ouvert
2026
article
OpenAlex
Darren M. Lipnicki, Meritxell Valenti, Elizabeth Lucia Valeriano‐Lorenzo, Ashleigh S. Vella et autres
Abstract INTRODUCTION Dreaming is subserved by the default mode network (DMN) and can be abolished by focal lesions within key regions. DMN dysfunction is promoted by pre‐clinical Alzheimer's pathology and apolipoprotein E ( APOE ) ε4 carriage, but any effects of these …
au, es
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Accès ouvert
2025
article
OpenAlex
Jesús Silva‐Rodríguez, Linda Zhang, Luca Kleineidam, Sonia Wagner et autres
BACKGROUND: %p-tau217 ratio has emerged as a promising plasma biomarker for Alzheimer's disease (AD) pathology, reaching performance levels comparable to CSF-based measures. However, its prognostic value in cognitively unimpaired (CU) individuals remains to be further explored. METHOD: We studied 982 CU older …
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Accès ouvert
2025
article
OpenAlex
Linda Zhang, Jesús Silva‐Rodríguez, Eva Alfayate, Sonia Wagner et autres
BACKGROUND: Plasma ptau217 has recently emerged as a reliable biomarker for early Alzheimer's disease (AD) pathology. Additionally, previous works have suggested that indices of cortical mean diffusivity (MD) derived from diffusion-weighted imaging are thought to reflect early microstructural changes preceding detectable structural …
es
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Accès ouvert
2025
article
OpenAlex
Cristina Cadenas‐Sánchez, Linda Zhang, Jesús Silva‐Rodríguez, Elizabeth Lucia Valeriano‐Lorenzo et autres
BACKGROUND: Plasma p-tau217 is an emerging biomarker for Alzheimer's disease (AD) and has been shown to be a strong predictor of cognitive decline even in cognitively unimpaired (CU) individuals. However, little is known about the association of elevated plasma p-tau217 with long-term …
es
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Accès ouvert
2025
article
OpenAlex
Darren M. Lipnicki, Meritxell Valenti, Elizabeth Lucia Valeriano‐Lorenzo, Ashleigh S. Vella et autres
Abstract Background Evidence suggests that dreaming is subserved by the default mode network (DMN) (Domhoff, 2022. The Neurocognitive Theory of Dreaming ). β‐amyloid plaques and phosphorylated tau ( p ‐tau) protein tangles accumulate and contribute to abnormal functionality in the DMN long …
au, es
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Accès ouvert
2025
article
OpenAlex
Linda Zhang, Jesús Silva‐Rodríguez, Eva Alfayate, Sonia Wagner et autres
BACKGROUND: Plasma ptau217 has recently emerged as a reliable biomarker for early Alzheimer's disease (AD) pathology. Additionally, previous works have suggested that indices of cortical mean diffusivity (MD) derived from diffusion-weighted imaging are thought to reflect early microstructural changes preceding detectable structural …
es
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Jesús Silva‐Rodríguez, Linda Zhang, Luca Kleineidam, Cristina Sánchez et autres
Abstract Background Plasma ptau‐217 has demonstrated excellent performance in detecting AD pathology. However, its value for predicting long‐term cognitive decline among cognitively unimpaired (CU) individuals remains unclear. Method We analyzed data from 1044 CU older individuals (75±4yrs, 64% female) enrolled in the …
es, de
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Accès ouvert
2025
article
OpenAlex
Elizabeth Lucia Valeriano‐Lorenzo, Mario Ricciardi, Sonia Wagner, Minerva Martinez et autres
Abstract Background Recent studies demonstrate an association between glial fibrillary acidic protein (GFAP) levels and post‐mortem tau pathology and highlighted its role as a link between amyloid and tau pathology in Alzheimer's disease (AD) [Sánchez‐Juan, Pascual, et al., Brain 147.5 (2024): 1667‐1679.]. …
es
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Accès ouvert
2025
article
OpenAlex
Cristina Sánchez, Linda Zhang, Jesús Silva‐Rodríguez, Elizabeth Lucia Valeriano‐Lorenzo et autres
Abstract Background Plasma p ‐tau217 is an emerging biomarker for Alzheimer's disease (AD) and has been shown to be a strong predictor of cognitive decline even in cognitively unimpaired (CU) individuals. However, little is known about the association of elevated plasma p …
es
(code pays fourni par la source)